Document 0555
 DOCN  M9480555
 TI    HIV-1 gp41 shares a common immunologic determinant with human T, B and
       monocyte cell lines.
 DT    9410
 AU    Chen YH; Susanna A; Bock G; Steindl F; Katinger H; Dierich MP;
       Ludwig-Boltzmann-Institute for AIDS-Research, Innsbruck, Austria.
 SO    Immunol Lett. 1994 Mar;39(3):219-22. Unique Identifier : AIDSLINE
       MED/94307758
 AB    Several examples of molecular mimicry between HIV-1 and human proteins
       are reported in the literature. Here we report on yet another example.
       The monoclonal antibody 3D6 recognized a 17-amino-acid region in HIV-1
       gp41 (amino acids 602-618) and could bind to the human T-cell lines H9
       and Molt4, B cell lines Raji and Bjab, and monocyte cell lines U937 and
       HL60. By Western blot using 3D6, a strong band of 43 kDa and a very weak
       band of 80 kDa were detected in lysates of H9, Molt4, Raji and Bjab cell
       lines, but only a strong band of 43 kDa was observed in case of U937 and
       HL60 cells, under reducing or non-reducing conditions. The results
       indicate the presence of a common immunologic determinant between HIV-1
       gp41 and membrane proteins of these human T, B and monocyte cells.
 DE    Amino Acid Sequence  Antibodies, Monoclonal  Antigenic
       Determinants/IMMUNOLOGY  B-Lymphocytes/*IMMUNOLOGY  Blotting, Western
       Cell Line  Flow Cytometry  Human  HIV Envelope Protein gp41/*IMMUNOLOGY
       HIV-1/*IMMUNOLOGY  Leukocytes/*IMMUNOLOGY  Molecular Sequence Data
       Monocytes/*IMMUNOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).